Health Report - Mangosteen - Supplement Benefits for Health and Longevity

Mangosteen Properties

Benefits of Mangosteen | Master Antioxidant

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Mangosteen along with acai and goji are the three superfoods in an amazing new antioxidant formula - CLICK for more detailsMangosteen Health Benefits

One of the most praised of tropical fruits, and certainly the most esteemed fruit in the family Guttiferae, the mangosteen, Garcinia mangostana L., is almost universally known or heard of by this name.

There are numerous variations in nomenclature: among Spanish-speaking people, it is called mangostan; to the French, it is mangostanier, mangoustanier, mangouste or mangostier; in Portuguese, it is mangostao, mangosta or mangusta; in Dutch, it is manggis or manggistan; in Vietnamese, mang cut; in Malaya, it may be referred to in any of these languages or by the local terms, mesetor, semetah, or sementah; in the Philippines, it is mangis or mangostan. Throughout the Malay Archipelago, there are many different spellings of names similar to most of the above.


The mangosteen tree is very slow-growing, erect, with a pyramidal crown; attains 20 to 82 ft (6-25 m) in height, has dark-brown or nearly black, flaking bark, the inner bark containing much yellow, gummy, bitter latex. The evergreen, opposite, short-stalked leaves are ovate-oblong or elliptic, leathery and thick, dark-green, slightly glossy above, yellowish-green and dull beneath; 3 1/2 to 10 in (9-25 cm) long, 1 3/4 to 4 in (4.5-10 cm) wide, with conspicuous, pale midrib. New leaves are rosy. Flowers, 1 1/2 to 2 in (4-5 cm) wide and fleshy, may be male or hermaphrodite on the same tree. The former are in clusters of 3-9 at the branch tips; there are 4 sepals and 4 ovate, thick, fleshy petals, green with red spots on the outside, yellowish-red inside, and many stamens though the aborted anthers bear no pollen. The hermaphrodite are borne singly or in pairs at the tips of young branchlets; their petals may be yellowish-green edged with red or mostly red, and are quickly shed. Back to Top


The fruit, capped by the prominent calyx at the stem end and with 4 to 8 triangular, flat remnants of the stigma in a rosette at the apex, is round, dark-purple to red-purple and smooth externally; 1 1/3 to 3 in (3.4-7.5 cm) in diameter. The rind is 1/4 to 3/8 in (6-10 mm) thick, red in cross-section, purplish-white on the inside. It contains bitter yellow latex and a purple, staining juice. There are 4 to 8 triangular segments of snow-white, juicy, soft flesh (actually the arils of the seeds). The fruit may be seedless or have 1 to 5 fully developed seeds, ovoid-oblong, somewhat flattened, 1 in (2.5 cm) long and 5/8 in (1.6 cm) wide, that cling to the flesh. The flesh is slightly acid and mild to distinctly acid in flavor and is acclaimed as exquisitely luscious and delicious.


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Origin and Distribution:

The place of origin of the mangosteen is unknown but is believed to be the Sunda Islands and the Moluccas; still, there are wild trees in the forests of Kemaman, Malaya. Corner suggests that the tree may have been first domesticated in Thailand, or Burma. It is much cultivated in Thailand –where there were 9,700 acres (4,000 ha) in 1965 –also in Kampuchea, southern Vietnam and Burma, throughout Malaya and Singapore. The tree was planted in Ceylon about 1800 and in India in 1881. There it succeeds in 4 limited areas –the Nilgiri Hills, the Tinnevelly district of southern Madras, the Kanya-kumani district at the southernmost tip of the Madras peninsula, and in Kerala State in southwestern India. Back to Top


The mangosteen tree is fairly common only in the provinces of Mindanao and Sulu (or Jolo) in the Philippines. It is relatively rare in Nth Queensland, where it has been tried many times since 1854, and poorly represented in tropical Africa (Zanzibar, Ghana, Gabon and Liberia). There were fruiting trees in greenhouses in England in 1855.


The mangosteen was introduced into Trinidad from the Royal Botanic Garden at Kew, England, between 1850 and 1860 and the first fruit was borne in 1875. It reached the Panama Canal Zone and Puerto Rico in 1903 but there are only a few trees in these areas, in Jamaica, Dominica and Cuba, and some scattered around other parts of the West Indies.


The United States Department of Agriculture received seeds from Java in 1906 (S.P.I. #17146). A large test block of productive trees has been maintained at the Lancetilla Experimental Station at Tela, Honduras, for many years. Quite a few trees distributed by the United Fruit Company long ago have done well on the Atlantic coast of Guatemala.  Back to Top


In 1924, Dr. Wilson Popenoe saw the mangosteen growing at one site in Ecuador. In 1939, 15,000 seeds were distributed by the Canal Zone Experiment Gardens to many areas of tropical America. It is probable that only a relatively few seedlings survived. It is known that many die during the first year. Dr. Victor Pati has observed flourishing mangosteen trees at the site of an old mining settlement in Mariquita, Colombia, in the Magdalena Valley and the fruits are sold on local markets. Dierberger Agricola Ltda., of Sao Paulo, included the mangosteen in their nursery catalog in 1949.


Despite early trials in Hawaii, the tree has not become well acclimatized and is still rare in those islands. Neither has it been successful in California. It encounters very unfavorable soil and climate in Florida. Some plants have been grown for a time in containers in greenhouses. One tree in a very protected coastal location and special soil lived to produce a single fruit and then succumbed to winter cold.


Despite the oft-repeated Old World enthusiasm for this fruit, it is not always viewed as worth the trouble to produce. In Jamaica, it is regarded as nice but overrated; not comparable to a good field-ripe pineapple or a choice mango. Back to Top



According to Corner, the fruit from seedling trees is fairly uniform; only one distinct variation is known and that is in the Sulu Islands. The fruit is larger, the rind thicker than normal, and the flesh more acid; the flavor more pronounced. In North Borneo, a seemingly wild form has only 4 carpels, each containing a fully-developed seed, and this is probably not unique.



The mangosteen is ultra-tropical. It cannot tolerate temperatures below 40º F (4.44º C), nor above 100º F (37.78º C). Nursery seedlings are killed at 45º F (7.22º C).


It is limited in Malaya to elevations below 1,500 ft (450 m). In Madras it grows from 250 to 5,000 ft (76-1,500 m) above sea-level. Attempts to establish it north of 200 latitude have all failed.


It ordinarily requires high atmospheric humidity and an annual rainfall of at least 50 in (127 cm), and no long periods of drought. In Dominica, mangosteen trees growing in an area having 80 in (200 cm) of rain yearly required special care, but those in another locality with 105 in (255 cm) and soil with better moisture- holding capacity, flourished. Back to Top


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The tree is not adapted to limestone and does best in deep, rich organic soil, especially sandy loam or laterite. In India, the most productive specimens are on clay containing much coarse material and a little silt. Sandy alluvial soils are unsuitable and sand low in humus contributes to low yields. The tree needs good drainage and the water table ought to be about 6 ft (1.8 m) below ground level. However, in the Canal Zone, productive mangosteen groves have been established where it is too wet for other fruit trees – in swamps requiring drainage ditches between rows and in situations where the roots were bathed with flowing water most of the year, in spite of the fact that standing water in nursery beds will kill seedlings. The mangosteen must be sheltered from strong winds and salt spray, as well as saline soil or water.



Technically, the so-called "seeds" are not true seeds but adventitious embryos, or hypocotyl tubercles, inasmuch as there has been no sexual fertilization. When growth begins, a shoot emerges from one end of the seed and a root from the other end. But this root is short-lived and is replaced by roots which develop at the base of the shoot. The process of reproduction being vegetative, there is naturally little variation in the resulting trees and their fruits. Some of the seeds are polyembryonic, producing more than one shoot. The individual nucellar embryos can be separated, if desired, before planting. Back to Top


Inasmuch as the percentage of germination is directly related to the weight of the seed, only plump, fully developed seeds should be chosen for planting. Even these will lose viability in 5 days after removal from the fruit, though they are viable for 3 to 5 weeks in the fruit. Seeds packed in lightly dampened peat moss, sphagnum moss or coconut fiber in airtight containers have remained viable for 3 months. Only 22% germination has been realized in seeds packed in ground charcoal for 15 days. Soaking in water for 24 hours expedites and enhances the rate of germination. Generally, sprouting occurs in 20 to 22 days and is complete in 43 days.


Because of the long, delicate taproot and poor lateral root development, transplanting is notoriously difficult. It must not be attempted after the plants reach 2 ft (60 cm). At that time the depth of the taproot may exceed that height. There is greater seedling survival if seeds are planted directly in the nursery row than if first grown in containers and then transplanted to the nursery. The nursery soil should be 3 ft (1 m) deep, at least. The young plants take 2 years or more to reach a height of 12 in (30 cm), when they can be taken up with a deep ball of earth and set out. Fruiting may take place in 7 to 9 years from planting but usually not for 10 or even 20 years. Back to Top


Conventional vegetative propagation of the mangosteen is difficult. Various methods of grafting have failed. Cuttings and air-layers, with or without growth-promoting chemicals, usually fail to root or result in deformed, short-lived plants. Inarching on different rootstocks has appeared promising at first but later incompatibility has been evident with all except G. xanthochymus Hook. f. (G tinctoria Dunn.) or G. lateriflora Bl., now commonly employed in the Philippines.


In Florida, approach-grafting has succeeded only by planting a seed of G. xanthochymus about 1 1/4 in (3 cm) from the base of a mangosteen seedling in a container and, when the stem of the G. xanthochymus seedling has become 1/8 in (3 mm) thick, joining it onto the 3/16 to 1/4 in (5-6 mm) thick stem of the mangosteen at a point about 4 in (10 cm) above the soil. When the graft has healed, the G. xanthochymus seedling is beheaded. The mangosteen will make good progress having both root systems to grow on, while the G. xanthochymus rootstock will develop very little. Back to Top


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A spacing of 35 to 40 ft (10.7-12 m) is recommended. Planting is preferably done at the beginning of the rainy season. Pits 4 x 4 x 4 1/2 ft (1.2 x l.2 x l.3 m) are prepared at least 30 days in advance, enriched with organic matter and topsoil and left to weather. The young tree is put in place very carefully so as not to injure the root and given a heavy watering. Partial shading with palm fronds or by other means should be maintained for 3 to 5 years. Indian growers give each tree regular feeding with well-rotted manure–100 to 200 lbs (45-90 kg)–and peanut meal–10 to 15 lbs (4.5-6.8 kg) total, per year.

Some of the most fruitful mangosteen trees are growing on the banks of streams, lakes, ponds or canals where the roots are almost constantly wet. However, dry weather just before blooming time and during flowering induces a good fruit-set. Where a moist planting site is not available, irrigation ditches should be dug to make it possible to maintain an adequate water supply and the trees are irrigated almost daily during the dry season.


In Malaya and Ceylon, it is a common practice to spread a mulch of coconut husks or fronds to retain moisture. A 16-in (40-cm) mulch of grass restored trees that had begun dehydrating in Liberia. It has been suggested that small inner branches be pruned from old, unproductive trees to stimulate bearing. In Thailand, the tree is said to take 12 to 20 years to fruit. In Panama and Puerto Rico trees grown from large seed and given good culture have borne in six years. Back to Top


Season and Harvesting

At low altitudes in Ceylon the fruit ripens from May to July; at higher elevations, in July and August or August and September. In India, there are 2 distinct fruiting seasons, one in the monsoon period (July-October) and another from April through June. Puerto Rican trees in full sun fruit in July and August; shaded trees, in November and December.


Cropping is irregular and the yield varies from tree to tree and from season to season. The first crop may be 200 to 300 fruits. Average yield of a full-grown tree is about 500 fruits. The yield steadily increases up to the 30th year of bearing when crops of 1,000 to 2,000 fruits may be obtained. In Madras, individual trees between the ages of 20 and 45 years have borne 2,000 to 3,000 fruits. Productivity gradually declines thereafter, though the tree will still be fruiting at 100 years of age.


Ripeness is gauged by the full development of color and slight softening. Picking may be done when the fruits are slightly under ripe but they must be fully mature (developed) or they will not ripen after picking. The fruits must be harvested by hand from ladders or by means of a cutting pole and not be allowed to fall. Back to Top


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Keeping Quality

In dry, warm, closed storage, mangosteen fruit can be held 20 to 25 days. Longer periods cause the outer skin to toughen and the rind to become rubbery; later, the rind hardens and becomes difficult to open and the flesh turns dry.


Ripe mangosteen fruit keeps well for 3 to 4 weeks in storage at 40º to 55º F (4º-12º C). Trials in India have shown that optimum conditions for cold storage are temperatures of 39º to 42º F (4º- 6º C) and relative humidity of 85 to 90%, which maintain quality for 49 days. It is recommended that the fruits be wrapped in tissue paper and packed 25-to-the-box in light wooden crates with excelsior padding. Fruits picked slightly unripe have been shipped from Burma to the United Kingdom at 50º to 55º F (10º-12º C). From 1927 to 1929, trial shipments were made from Java to Holland at 37º F (approximately 2º C) and the fruits kept in good condition for 24 days. Back to Top


Pests and Diseases

Few pests have been reported. A leaf-eating caterpillar in India may perhaps be the same as that which attacks new shoots in the Philippines and which has been identified as Orgyra sp. of the tussock moth family, Lymantridae. A small ant, Myrnelachista ramulorum, in Puerto Rico, colonizes the tree, tunnels into the trunk and branches, and damages the new growth. Mites sometimes deface the fruits with small bites and scratches. Fully ripe fruits are attacked by monkeys, bats and rats in Asia.

In Puerto Rico, thread blight caused by the fungus, Pellicularia koleroga, is often seen on branchlets, foliage and fruits of trees in shaded, humid areas. The fruits may become coated with webbing and ruined. In Malaya, the fungus, Zignoella garcineae, gives rise to "canker"–tuberous growths on the branches, causing a fatal dying-back of foliage, branches and eventually the entire tree. Breakdown in storage is caused by the fungi Diplodia gossypina, Pestalotia sp., Phomopsis sp., Gloeosporium sp., and Rhizopus nigricans.


A major physiological problem called "gamboge" is evidenced by the oozing of latex onto the outer surface of the fruits and on the branches during periods of heavy and continuous rains. It does not affect eating quality. Fruit-cracking may occur because of excessive absorption of moisture. In cracked fruits the flesh will be swollen and mushy. Bruising caused by the force of storms may be an important factor in both of these abnormalities. Fruits exposed to strong sun may also exude latex. Mangosteens produced in Honduras often have crystal-like "stones" in the flesh and they may render the fruit completely inedible.


Food Uses Back to Top

To select the best table fruits, choose those with the highest number of stigma lobes at the apex, for these have the highest number of fleshy segments and accordingly the fewest seeds. The numbers always correspond. Mangosteens are usually eaten fresh as dessert. One need only hold the fruit with the stem-end downward, take a sharp knife and cut around the middle completely through the rind, and lift off the top half, which leaves the fleshy segments exposed in the colorful "cup"–the bottom half of the rind. The segments are lifted out by fork.


The fleshy segments are sometimes canned, but they are said to lose their delicate flavor in canning, especially if pasteurized for as much as 10 minutes. Tests have shown that it is best to use a 40% sirup and sterilize for only 5 minutes. The more acid fruits are best for preserving. To make jam, in Malaya, seedless segments are boiled with an equal amount of sugar and a few cloves for 15 to 20 minutes and then put into glass jars. In the Philippines, a preserve is made by simply boiling the segments in brown sugar, and the seeds may be included to enrich the flavor.


The seeds are sometimes eaten alone after boiling or roasting.


The rind is rich in pectin. After treatment with 6% sodium chloride to eliminate astringency, the rind can be made into a purplish jelly. Back to Top


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Health Benefits

Mangosteen is a fruit found in tropical countries throughout Asia, for example Thailand, India, Malaysia, Vietnam and the Philippines. It also grows very well in areas such as Hawaii and tropical Northern Australia.

The fruit consist of 3 major parts.

The Mangosteen Pericarp - which is the rind or peel and contains the highest level of xanthones.

The pulp -  which is the fruit and is known for being one of the tastiest fruits in the world.

The seeds -  Found within the white pulp.

Properties: Back to Top

Mangosteen fruit contains compounds that have antioxidant - anti-bacterial and anti-fungal properties. Scientific research indicates activity against several cancer cell lines, including breast cancer, liver cancer and leukemia. In addition, Mangosteen also exhibits  anti-histamine and anti-inflammatory properties. Traditionally, mangosteen has been used for many years as a medicinal treatment for diarrhea, skin infection and wounds in throughout South Asia.

The latest in scientific research shows mangosteen contains a class of naturally occurring polyphenolic compounds known as xanthones. Xanthones may provide beneficial effects on cardiovascular diseases, including ischemic heart disease, atherosclerosis, hypertension, and thrombosis. Mangosteen also shows vasorelaxant properties.

Mangosteen has demonstrated an inhibitory action against the bacterial organisms Mycobacterium tuberculosis, Staphylococcus aureus. Mangosteen is also proving to be highly effective in supporting and strengthening a weak immune system. There are several important compounds found in the Mangosteen that would appear to make this fruit an active and important nutritional supplement for the human body.  Back to Top

Mangosteen Xanthones are broken down even further into mangostin, mangostenol, mangostenone A, Mangostenone B, trapezifolixanthone, tovophyllin B, alpha- and beta-mangostins, garcinone B, mangostinone, mangostanol and the flavonoid epicatechin. A study of the antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana on SKBR3 human breast cancer cell line, showed SKBR3 cells were cultured in the presence of mangosteen extract at various concentrations. Mangosteen showed a dose dependent inhibition of cell proliferation. "We found that an antiproliferative effect of mangosteen was associated with apoptosis on breast cancer cell line by determinations of morphological changes and oligonucleosomal DNA fragments."

Mangosteen also was found to inhibit ROS production. These investigations suggest that mangosteen has strong anti-proliferation, potent anti-oxidation and induction of apoptosis properties. Mangosteen has potential for cancer chemoprevention, which is dose dependent as well as exposure time dependent. The ethanol extract of Mangosteen showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active known compounds. The chemical structures of the isolated compounds were established by spectroscopic analysis as mangostin and gamma-mangostin.

Potential Benefits of Mangosteen



Free radical fighter

Cardio support

Immune system Enhancer

Powerful antioxidant

Skin rashes, infections and wounds





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References and Studies:

Tapiero, H., et. al. “Polyphenols: do they play a role in the prevention of human pathologies?” Biomedicine & Pharmacotheraphy; 2002, 56 (4):200-207

Huang, D., et. al. “High-throughout assay of oxygen radical absorbency capacity using multichannel liquid handling system coupled with a microplate florescence reader in 96 we format.” Journal of Agricultural and Food Chemistry: 2002 50 (16): 4437-4444

Mangosteen in the Columbia Encyclopedia - 6th edition, Columbia University Press 2003

Parkinson. R. “Mangoes, Lychees and Mangosteen": Chinese Cuisine 2004

Nakatani, K. , et. al. “gamma-Mangostin inhibits IkappaB Kinase Activity with and decreases Lipopolysaccaride-induced cyclooxgenanase-2 Gene Expression in C6 Rat glioma Cells.” Molecular Pharmacology; June 24, 2004

Jiang, D.J. e. al. “ Pharmacological effects of xanthones as cardiovascular protective agents.” Cardiovascular Drug Reviews , 2004, 22(2):91-102

Biochem Pharmacol - 2002 Jan 1;63(1):73-9

Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives – J. Nat Prod 1997 May; 60 (5):519-24

Active constituents against HIV-1 protease from Mangosteen- Planta Med 1996 Aug;62(4):381-2

Mangostin inhibits the oxidative modification of human low density lipoprotein- Free radical Res. 1995 Aug.:23(2):175-84

Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana on SKBR3 human breast cancer cell line J.Ethnopharmacol, 2004 Jan:90(1):161-6

Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines J.Nat Prod. 2003 Aug;55(8):1124-7

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